Nicole E Winchester, Frank Maldarelli, Yolanda Mejia, Nicola Dee, Robin Dewar, Elizabeth Laidlaw, Safia S Kuriakose, Pamela Stoll, Michael Proschan, H Clifford Lane, Alice K Pau, Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool For Preventing Unnecessary ART Changes and Optimizing Adherence Support, Clinical Infectious Diseases, Volume 70, Issue 6, 15 March 2020, Pages 1222–1225, https://doi.org/10.1093/cid/ciz590
Abstract
Eight-day inpatient directly observed therapy confirmed nonadherence as the major cause of virologic failure for 9 (45%) of 20 highly treatment-experienced persons with human immunodeficiency virus, extensive antiretroviral drug resistance, and high self-reported adherence rates, preventing unnecessary regimen changes.